Restylane is a synthetic substance that mimics the naturally occurring gel like material in the deeper layers of the skin – hyaluronic acid (a so called ground substance). It is injected into finer wrinkles often around the lower brow and mouth but is also used in lip enhancement. It has a life of around six months and injections usually therefore need to be repeated. There is a risk of around 1:500 of reactions to the injection.
Sculptra is a substance used to enhance the deeper soft tissues of the face. It is similar in its formulation to some types of dissolvable suture material. It requires two injections separated by around 5 weeks and usually lasts around 18 months. Like Restylane, there is a small risk of reaction to the injected material.